
Sudden infant death syndrome (SIDS), which is the leading cause of death for infants between 1 and 12 months old in the United States, has long mystified doctors and researchers.
Now, after more than 20 years of research, researchers at Children’s Hospital Boston are taking the next step and have linked SIDS with low production of serotonin in the brainstem. The findings, published in the Feb. 3 issue of The Journal of the American Medical Association, may give a concrete approach to identifying babies at risk for SIDS.
In the brainstem, serotonin helps regulate some of the body’s involuntary actions, such as breathing, heart rate and blood pressure during sleep. The researchers, led by Children’s neuropathologist Hannah Kinney, MD, believe that a low serotonin level impairs the function of the brainstem circuits that regulate these activities, putting a baby at risk for sudden death from stresses such as rebreathing carbon dioxide when sleeping in the face down position.
The future goal of this work is to devise a test to identify infants with a serotonin brainstem defect early, and to develop preventive treatments that would correct the serotonin deficiency.
In 2006, Kinney and colleagues showed that SIDS is associated with abnormalities in the number of cells and receptors related to serotonin in the brainstem, but it wasn’t clear whether SIDS may be caused by overproduction or underproduction of the chemical.